The radio program aired from October 19, 1937, to June 25, 1952. It was produced by William N. Robson and Crane Wilbur, and written by Jerry McGill. Theme music was by Fran Frey. Edward G. Robinson had the lead role of Steve Wilson, crusading editor of the Illustrated Press, from 1937 to 1943. Claire Trevor was Wilson's reporter sidekick "Lorelei," with Ona Munson taking over that role in 1939. The female lead evolved from the initial script's description as "the society editor who writes under the name of 'Lorelei' to star crime reporter "Lorelei Kilbourne," with no hint that her first name was a stylized byline. She provided the tabloid-minded Wilson with a conscience in the early episodes, not unlike the editor's secretary in Robinson's Oscar-nominated Five Star Final in 1931.
Edward J. Pawley portrayed Steve Wilson from 1943 until 1952 when Walter Greaza was heard as Wilson in the final episodes. Fran Carlon played Lorelei to Pawley's Wilson from 1943 to 1952. During the period in which Pawley starred, Big Town was rated No. 1 among all of the reporter-type drama series on radio. It was also rated in the top 12 among all radio programs broadcast and had a listening audience rated between 10 and 20 million people.
Ken Niles was the announcer.